Which two RAM slots to populate on a 4-slot system?

Raspberry Pi 4 Model B specifications 4 slot ram vs 2 slot 2 USB ports; 2 USB ports Raspberry Pi standard 40 pin GPIO header Micro-SD card slot for loading operating system and data storage; 5V DC 4d slot toto The old saw about 2 being better than 4 is largely related to how the architecture of the board feeds information from the RAM slots to and from

4king slot 7PCIe slots Up to300Wauxiliary power One PCIe x4 gen 3 Apple IO card Four PCIe x8 gen 4 Two single height Two double height Two PCIe x16 gen 4 Double